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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
14/10/2015 |
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Data da última atualização: |
03/12/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
JESUS, D. R.; BARBOSA, L. N.; PRANDO, T. B. L.; MARTINS, L. F.; GASPAROTTO, F.; GUEDES, K. M. R.; DRAGUNSKI, D. C.; LOURENÇO, E. L. B.; DALSENTER, P. R.; GASPAROTTO JUNIOR, A. |
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Afiliação: |
DOUGLAS ROSSI JESUS, UNIPAR - Universidade Paranaense; LORENA NERIS BARBOSA, UFPR; THIAGO BRUNO LIMA PRANDO, UNIPAR; LEONARDO FRANCO MARTINS, UNIPAR; FRANCIELLI GASPAROTTO, CESUMAR; KARLA MORAES ROCHA GUEDES, CPAP; DOUGLAS CARDOSO DRAGUNSKI, UNIPAR; EMERSON LUIZ BOTELHO LOURENÇO, UNIPAR; PAULO ROBERTO DALSENTER, UFPR; ARQUIMEDES GASPAROTTO JUNIOR, UFGD. |
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Título: |
Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Evidence-Based Complementary and Alternative Medicine, 2015. |
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DOI: |
10.1155/2015/390416 |
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Idioma: |
Inglês |
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Conteúdo: |
The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm. |
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Palavras-Chave: |
Biodegradable films; Degradable products; FCSA. |
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Thesagro: |
Mandioca; Manihot Esculenta; Tóxico. |
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Thesaurus Nal: |
Biodegradation. |
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Categoria do assunto: |
E Economia e Indústria Agrícola |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/134837/1/Ninety-Day-Oral-Toxicity-Assessment-of-an-Alternative.pdf
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Marc: |
LEADER 01972naa a2200325 a 4500
001 2026401
005 2015-12-03
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1155/2015/390416$2DOI
100 1 $aJESUS, D. R.
245 $aNinety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
260 $c2015
520 $aThe large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.
650 $aBiodegradation
650 $aMandioca
650 $aManihot Esculenta
650 $aTóxico
653 $aBiodegradable films
653 $aDegradable products
653 $aFCSA
700 1 $aBARBOSA, L. N.
700 1 $aPRANDO, T. B. L.
700 1 $aMARTINS, L. F.
700 1 $aGASPAROTTO, F.
700 1 $aGUEDES, K. M. R.
700 1 $aDRAGUNSKI, D. C.
700 1 $aLOURENÇO, E. L. B.
700 1 $aDALSENTER, P. R.
700 1 $aGASPAROTTO JUNIOR, A.
773 $tEvidence-Based Complementary and Alternative Medicine, 2015.
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Registro original: |
Embrapa Pantanal (CPAP) |
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| Registros recuperados : 3 | |
| 1. |  | GASPAROTTO, F. A.; NAVARRETE, A. A.; SOUZA, F. A. de; TSAI, S. M. Técnicas moleculares aplicadas ao estudo de micorrizas. In: SIQUEIRA, J. O.; SOUZA, F. A. de; CARDOSO, E. J. B. N.; TSAI, S. M. (Ed.). Micorrizas: 30 anos de pesquisas no Brasil. Lavras: UFLA, 2010. cap. 19, p. 551-581.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 2. | | GASPAROTTO, F.; VIDA, J. B.; VERZIGNASSI, J. R.; BONALDO, S. M.; TESSMANN, D. J.; COLELLA, J. C. T. Caracterização sintomatológica de Didymella bryoniae em meloeiro nobre. Summa Phytopathologica, Botucatu, v. 33, p. S.42, 2007. Suplemento. Título em inglês: Symptons of gummy stem bligth in muskmelon.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
|  |
| 3. | | JESUS, D. R.; BARBOSA, L. N.; PRANDO, T. B. L.; MARTINS, L. F.; GASPAROTTO, F.; GUEDES, K. M. R.; DRAGUNSKI, D. C.; LOURENÇO, E. L. B.; DALSENTER, P. R.; GASPAROTTO JUNIOR, A. Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate. Evidence-Based Complementary and Alternative Medicine, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pantanal. |
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| Registros recuperados : 3 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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